PYGM Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - starch and sucrose; EC; Endoplasmic reticulum; Phosphorylase; Transferase
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  glycogen phosphorylase activity; linear malto-oligosaccharide phosphorylase activity; nucleotide binding; protein binding; pyridoxal phosphate binding; SHG alpha-glucan phosphorylase activity
Biological Process:  glycogen catabolic process; glycogen metabolic process
Disease: Glycogen Storage Disease V
Reference #:  P11217 (UniProtKB)
Alt. Names/Synonyms: glycogen phosphorylase, muscle associated; Glycogen phosphorylase, muscle form; GSD5; Myophosphorylase; phosphorylase, glycogen, muscle; PYGM
Gene Symbols: PYGM
Molecular weight: 97,092 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene