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PYGM
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase |
| Chromosomal Location of human Ortholog: 11q13.1 |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
glycogen phosphorylase activity; linear malto-oligosaccharide phosphorylase activity; nucleotide binding; protein binding; pyridoxal phosphate binding; SHG alpha-glucan phosphorylase activity
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Biological Process:
glycogen catabolic process; glycogen metabolic process
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Disease: Glycogen Storage Disease V
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Reference #:
P11217
(UniProtKB)
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Alt. Names/Synonyms: glycogen phosphorylase, muscle associated; Glycogen phosphorylase, muscle form; GSD5; Myophosphorylase; phosphorylase, glycogen, muscle; PYGM
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Gene Symbols: PYGM
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Molecular weight:
97,092 Da
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Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
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