TrkA iso2 a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  axon; cell surface; cytoplasm; cytoplasmic vesicle; dendrite; early endosome; early endosome membrane; Golgi membrane; integral component of plasma membrane; late endosome; late endosome membrane; neuronal cell body; plasma membrane; protein-containing complex; receptor complex; recycling endosome; recycling endosome membrane
Molecular Function:  ATP binding; GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; neurotrophin p75 receptor binding; neurotrophin receptor activity; protein binding; protein homodimerization activity; protein tyrosine kinase activity; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  aging; axon guidance; axonogenesis involved in innervation; B cell differentiation; behavioral response to formalin induced pain; cellular response to growth factor stimulus; cellular response to nerve growth factor stimulus; cellular response to nicotine; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; innervation; learning or memory; mechanoreceptor differentiation; negative regulation of cell proliferation; negative regulation of neuron apoptotic process; negative regulation of neuron death; nerve growth factor signaling pathway; nervous system development; neuron development; neuron projection development; neurotrophin signaling pathway; neurotrophin TRK receptor signaling pathway; olfactory nerve development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of programmed cell death; positive regulation of protein phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of synapse assembly; positive regulation of synaptic transmission, glutamatergic; programmed cell death involved in cell development; protein autophosphorylation; protein phosphorylation; regulation of MAPK cascade; response to activity; response to axon injury; response to drug; response to electrical stimulus; response to ethanol; response to hydrostatic pressure; response to nicotine; response to nutrient levels; response to radiation; sensory perception of pain; Sertoli cell development; sympathetic nervous system development; transmembrane receptor protein serine/threonine kinase signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P35739-2 (UniProtKB)
Alt. Names/Synonyms: High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Ntrk1; p140-TrkA; Slow nerve growth factor receptor; Trk; Trk-A; Trka; trkA proto-oncogene receptor
Gene Symbols: Ntrk1
Molecular weight: 87,252 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TrkA iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene