14-3-3 zeta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15|15 B3.1
Cellular Component:  cell leading edge; cytoplasm; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; mitochondrion; nucleus; perinuclear region of cytoplasm; postsynaptic density; protein-containing complex
Molecular Function:  identical protein binding; ion channel binding; protein binding; protein domain specific binding; protein kinase binding; protein-containing complex binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  establishment of Golgi localization; Golgi reassembly; histamine secretion by mast cell; protein targeting; protein targeting to mitochondrion; regulation of cell death; regulation of synapse maturation; response to drug; synaptic target recognition
Reference #:  P63101 (UniProtKB)
Alt. Names/Synonyms: 1110013I11Rik; 14-3-3 protein zeta/delta; 1433Z; AI596267; AL022924; AU020854; KCIP-1; OTTMUSP00000018478; OTTMUSP00000018479; OTTMUSP00000018480; Protein kinase C inhibitor protein 1; SEZ-2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Ywhaz
Gene Symbols: Ywhaz
Molecular weight: 27,771 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 zeta

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene