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14-3-3 zeta
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. Belongs to the 14-3-3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 15|15 B3.1 |
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Cellular Component:
cell leading edge; cytoplasm; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; nucleus; perinuclear region of cytoplasm; postsynaptic specialization; protein-containing complex
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Molecular Function:
DNA-binding transcription factor binding; identical protein binding; phosphoserine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein sequestering activity; protein-containing complex binding; transmembrane transporter binding; ubiquitin protein ligase binding
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Biological Process:
angiogenesis; ERK1 and ERK2 cascade; establishment of Golgi localization; Golgi reassembly; histamine secretion by mast cell; lung development; negative regulation of innate immune response; negative regulation of protein localization to nucleus; negative regulation of transcription by RNA polymerase II; protein phosphorylation; protein targeting; protein targeting to mitochondrion; regulation of ERK1 and ERK2 cascade; regulation of programmed cell death; regulation of synapse maturation; respiratory system process; response to xenobiotic stimulus; signal transduction; synaptic target recognition; tube formation
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Reference #:
P63101
(UniProtKB)
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Alt. Names/Synonyms: 1110013I11Rik; 14-3-3 protein zeta/delta; 14-3-3 zeta; 14-3-3zeta; 1433Z; AI596267; AL022924; AU020854; KCIP-1; OTTMUSP00000018478; OTTMUSP00000018479; OTTMUSP00000018480; Protein kinase C inhibitor protein 1; SEZ-2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Ywhaz
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Gene Symbols: Ywhaz
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Molecular weight:
27,771 Da
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Basal Isoelectric point:
4.73
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Hippo Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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