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14-3-3 eta
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. Belongs to the 14-3-3 family. Expressed mainly in the brain and present in other tissues albeit at lower levels. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 22q12.3 |
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Cellular Component:
cerebellar granule cell to Purkinje cell synapse; cytoplasm; cytosol; intercalated disc; plasma membrane; presynapse
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Molecular Function:
actin binding; enzyme binding; identical protein binding; insulin-like growth factor receptor binding; nuclear glucocorticoid receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; sodium channel regulator activity; transmembrane transporter binding
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Biological Process:
glucocorticoid catabolic process; glucocorticoid receptor signaling pathway; intracellular protein transport; membrane depolarization during action potential; negative regulation of dendrite morphogenesis; positive regulation of DNA-templated transcription; presynaptic modulation of chemical synaptic transmission; regulation of neuron differentiation; regulation of sodium ion transmembrane transporter activity; regulation of sodium ion transport; regulation of synaptic plasticity; signal transduction
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Reference #:
Q04917
(UniProtKB)
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Alt. Names/Synonyms: 14-3-3 eta; 14-3-3 protein eta; 1433F; Protein AS1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1; YWHAH
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Gene Symbols: YWHAH
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Molecular weight:
28,219 Da
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Basal Isoelectric point:
4.76
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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