14-3-3 eta Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. Belongs to the 14-3-3 family. Expressed mainly in the brain and present in other tissues albeit at lower levels. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component:  cytoplasm; cytosol; intercalated disc; mitochondrion; plasma membrane
Molecular Function:  actin binding; enzyme binding; glucocorticoid receptor binding; identical protein binding; insulin-like growth factor receptor binding; ion channel binding; protein binding; protein domain specific binding; protein heterodimerization activity; sodium channel regulator activity
Biological Process:  glucocorticoid catabolic process; glucocorticoid receptor signaling pathway; intracellular protein transport; membrane depolarization during action potential; membrane organization; negative regulation of dendrite morphogenesis; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of transcription, DNA-templated; regulation of neuron differentiation; regulation of sodium ion transmembrane transporter activity; regulation of sodium ion transport; regulation of synaptic plasticity
Reference #:  Q04917 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 eta; 14-3-3 protein eta; 1433F; Protein AS1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1; YWHAH
Gene Symbols: YWHAH
Molecular weight: 28,219 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 eta

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB