14-3-3 zeta Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. Belongs to the 14-3-3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of human Ortholog: 8q22.3

Cellular Component: cytoplasm; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; melanosome; nucleoplasm

Molecular Function: DNA-binding transcription factor binding; identical protein binding; phosphoserine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein sequestering activity; transmembrane transporter binding; ubiquitin protein ligase binding

Biological Process: angiogenesis; ERK1 and ERK2 cascade; establishment of Golgi localization; Golgi reassembly; lung development; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; protein localization; protein phosphorylation; protein targeting; regulation of ERK1 and ERK2 cascade; regulation of synapse maturation; respiratory system process; signal transduction; synaptic target recognition; tube formation

Disease: Popov-chang Syndrome

Reference #: P63104 (UniProtKB)

Alt. Names/Synonyms: 14-3-3 delta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3-zeta; 1433Z; epididymis luminal protein 4; epididymis secretory protein Li 3; epididymis secretory protein Li 93; HEL-S-3; HEL-S-93; HEL4; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; POPCHAS; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; YWHAD; YWHAZ

Gene Symbols: YWHAZ

Molecular weight: 27,745 Da

Basal Isoelectric point: 4.73 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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14-3-3 zeta

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