| 14-3-3 zeta Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. Belongs to the 14-3-3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 8q22.3 |
| Cellular Component: cytoplasm; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; melanosome; mitochondrion; nucleoplasm |
| Molecular Function: identical protein binding; ion channel binding; protein binding; protein domain specific binding; protein kinase binding; transcription factor binding; ubiquitin protein ligase binding |
| Biological Process: cytokine-mediated signaling pathway; establishment of Golgi localization; Golgi reassembly; membrane organization; negative regulation of apoptotic process; platelet activation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein targeting; regulation of mRNA stability; regulation of synapse maturation; signal transduction; synaptic target recognition |
| Disease: Popov-chang Syndrome |
| Reference #: P63104 (UniProtKB) |
| Alt. Names/Synonyms: 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3-zeta; 1433Z; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; YWHAZ |
| Gene Symbols: YWHAZ |
| Molecular weight: 27,745 Da |
| Basal Isoelectric point: 4.73 Predict pI for various phosphorylation states |
| CST Pathways: Actin Dynamics | Apoptosis Regulation | G2/M DNA Damage Checkpoint | Growth And Differentiation Control by MAPKs | Hippo Signaling | Mitochondrial Control of Apoptosis | PI3K/Akt Signaling | SAPK/JNK Signaling Cascades |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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14-3-3 zeta |
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| Cross-references to other databases:
STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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