14-3-3 zeta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization. Note: This description may include information from UniProtKB.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: cytoplasm; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; melanosome; mitochondrion; nucleoplasm

Molecular Function: identical protein binding; ion channel binding; protein binding; protein domain specific binding; protein kinase binding; transcription factor binding; ubiquitin protein ligase binding

Biological Process: cytokine-mediated signaling pathway; establishment of Golgi localization; Golgi reassembly; membrane organization; negative regulation of apoptotic process; platelet activation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein targeting; regulation of mRNA stability; regulation of synapse maturation; signal transduction; synaptic target recognition

Disease: Popov-chang Syndrome

Reference #: P63104 (UniProtKB)

Alt. Names/Synonyms: 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3-zeta; 1433Z; KCIP-1; MGC111427; MGC126532; MGC138156; phospholipase A2; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; YWHAZ

Gene Symbols: YWHAZ

Molecular weight: 27,745 Da

Basal Isoelectric point: 4.73 Predict pI for various phosphorylation states

Protein-Specific Antibodies or siRNAs from Cell Signaling Technology^®

Select Structure to View Below
14-3-3 zeta

Get PyMOL Script Get ChimeraX Script