ATP6AP2 Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: X|X A1.1
Cellular Component:  apical plasma membrane; cell body; external side of plasma membrane; extracellular space; integral component of membrane; membrane; neuron projection
Molecular Function:  signaling receptor activity
Biological Process:  angiotensin maturation; eye pigmentation; head morphogenesis; positive regulation of transforming growth factor beta1 production; positive regulation of Wnt signaling pathway; regulation of MAPK cascade; rostrocaudal neural tube patterning
Reference #:  Q9CYN9 (UniProtKB)
Alt. Names/Synonyms: (P)RR; (pro)renin receptor; 5730403E06Rik; APT6M8-9; Atp; Atp6ap2; Atp6ip2; ATP6M8-9; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal accessory protein 2; ATPase, H+ transporting, lysosomal interacting protein 1; ATPase, H+ transporting, lysosomal interacting protein 2; M8-9; OTTMUSP00000018429; prorenin receptor; PRR; Renin receptor; Renin receptor cytoplasmic fragment; Renin receptor extracellular fragment; Renin/prorenin receptor; RENR
Gene Symbols: Atp6ap2
Molecular weight: 39,092 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein