MACROD1
Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. Note: This description may include information from UniProtKB.
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Protein type: EC 3.5.1.-; Mitochondrial |
Chromosomal Location of human Ortholog: 11q13.1 |
Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
ADP-ribosylglutamate hydrolase activity; deacetylase activity; hydrolase activity, acting on glycosyl bonds; protein binding
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Biological Process:
DNA damage response; peptidyl-glutamate ADP-deribosylation; protein de-ADP-ribosylation; purine nucleoside metabolic process
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Reference #:
Q9BQ69
(UniProtKB)
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Alt. Names/Synonyms: [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; LRP16; MACD1; MACRO domain containing 1; MACRO domain-containing protein 1; MACROD1; mono-ADP ribosylhydrolase 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16
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Gene Symbols: MACROD1
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Molecular weight:
35,505 Da
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Basal Isoelectric point:
9.58
Predict pI for various phosphorylation states
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