MACROD1 Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.-; Mitochondrial
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  ADP-ribosylglutamate hydrolase activity; deacetylase activity; hydrolase activity, acting on glycosyl bonds; protein binding
Biological Process:  DNA damage response; peptidyl-glutamate ADP-deribosylation; protein de-ADP-ribosylation; purine nucleoside metabolic process
Reference #:  Q9BQ69 (UniProtKB)
Alt. Names/Synonyms: [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; LRP16; MACD1; MACRO domain containing 1; MACRO domain-containing protein 1; MACROD1; mono-ADP ribosylhydrolase 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16
Gene Symbols: MACROD1
Molecular weight: 35,505 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
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MACROD1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein