nestin iso2 Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Belongs to the intermediate filament family. CNS stem cells. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of rat Ortholog: 2q34
Cellular Component:  cytoplasm; intermediate filament; intermediate filament cytoskeleton
Molecular Function:  CCR5 chemokine receptor binding; intermediate filament binding
Biological Process:  brain development; cell projection morphogenesis; embryonic camera-type eye development; G2/M transition of mitotic cell cycle; negative regulation of catalytic activity; negative regulation of neuron apoptotic process; negative regulation of protein binding; nervous system development; neuron apoptotic process; neuron differentiation; positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; response to ionizing radiation; response to nutrient levels; response to xenobiotic stimulus; stem cell proliferation
Reference #:  P21263-2 (UniProtKB)
Alt. Names/Synonyms: Nes; NEST; Nestin; nestin iso2
Gene Symbols: Nes
Molecular weight: 198,623 Da
Basal Isoelectric point: 4.31  Predict pI for various phosphorylation states
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nestin iso2

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene