nestin iso2
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Belongs to the intermediate filament family. CNS stem cells. Note: This description may include information from UniProtKB.
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Protein type: Cytoskeletal |
Chromosomal Location of rat Ortholog: 2q34 |
Cellular Component:
cytoplasm; intermediate filament; intermediate filament cytoskeleton
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Molecular Function:
CCR5 chemokine receptor binding; intermediate filament binding
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Biological Process:
brain development; cell projection morphogenesis; embryonic camera-type eye development; G2/M transition of mitotic cell cycle; negative regulation of catalytic activity; negative regulation of neuron apoptotic process; negative regulation of protein binding; nervous system development; neuron apoptotic process; neuron differentiation; positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; response to ionizing radiation; response to nutrient levels; response to xenobiotic stimulus; stem cell proliferation
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Reference #:
P21263-2
(UniProtKB)
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Alt. Names/Synonyms: Nes; NEST; Nestin; nestin iso2
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Gene Symbols: Nes
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Molecular weight:
198,623 Da
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Basal Isoelectric point:
4.31
Predict pI for various phosphorylation states
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