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TSC2 iso2
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor |
| Chromosomal Location of rat Ortholog: 10q12 |
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Cellular Component:
caveola; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; glutamatergic synapse; Golgi apparatus; growth cone; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; neuron projection; neuronal cell body; nucleus; perinuclear region of cytoplasm; postsynaptic density; protein-containing complex; synapse; TSC1-TSC2 complex
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Molecular Function:
14-3-3 protein binding; GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding; small GTPase binding
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Biological Process:
aging; anoikis; cell projection organization; cellular response to insulin stimulus; establishment of cell polarity; establishment of protein localization; glucose import; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of axonogenesis; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of fibroblast proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of MAP kinase activity; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of pinocytosis; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of TOR signaling; negative regulation of TORC1 signaling; negative regulation of vascular endothelial cell proliferation; negative regulation of Wnt signaling pathway; neural tube closure; phosphatidylinositol 3-kinase signaling; positive chemotaxis; positive regulation of autophagy; positive regulation of cell adhesion; positive regulation of dendritic spine development; positive regulation of fibroblast migration; positive regulation of GTPase activity; positive regulation of macroautophagy; positive regulation of neuron projection development; positive regulation of transcription by RNA polymerase II; protein heterooligomerization; protein homooligomerization; protein import into nucleus; protein kinase B signaling; protein localization; protein localization to cell surface; protein transport into plasma membrane raft; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of postsynapse organization; regulation of small GTPase mediated signal transduction; response to hypoxia; signal transduction; social behavior
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Reference #:
P49816-2
(UniProtKB)
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Alt. Names/Synonyms: Rc; renal carcinoma; Tsc2; TSC2 iso2; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein homolog
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Gene Symbols: Tsc2
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Molecular weight:
196,527 Da
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Basal Isoelectric point:
6.67
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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