TSC2 iso2 In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 10q12

Cellular Component: caveola; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; glutamatergic synapse; Golgi apparatus; growth cone; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; neuron projection; neuronal cell body; nucleus; perinuclear region of cytoplasm; postsynaptic density; protein-containing complex; synapse; TSC1-TSC2 complex

Molecular Function: 14-3-3 protein binding; GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding; small GTPase binding

Biological Process: aging; anoikis; cell projection organization; cellular response to insulin stimulus; establishment of cell polarity; establishment of protein localization; glucose import; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of axonogenesis; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of fibroblast proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of MAP kinase activity; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of pinocytosis; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of TOR signaling; negative regulation of TORC1 signaling; negative regulation of vascular endothelial cell proliferation; negative regulation of Wnt signaling pathway; neural tube closure; phosphatidylinositol 3-kinase signaling; positive chemotaxis; positive regulation of autophagy; positive regulation of cell adhesion; positive regulation of dendritic spine development; positive regulation of fibroblast migration; positive regulation of GTPase activity; positive regulation of macroautophagy; positive regulation of neuron projection development; positive regulation of transcription by RNA polymerase II; protein heterooligomerization; protein homooligomerization; protein import into nucleus; protein kinase B signaling; protein localization; protein localization to cell surface; protein transport into plasma membrane raft; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of postsynapse organization; regulation of small GTPase mediated signal transduction; response to hypoxia; signal transduction; social behavior

Reference #: P49816-2 (UniProtKB)

Alt. Names/Synonyms: Rc; renal carcinoma; Tsc2; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein homolog

Gene Symbols: Tsc2

Molecular weight: 196,527 Da

Basal Isoelectric point: 6.67 Predict pI for various phosphorylation states

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TSC2 iso2

Cross-references to other databases: Pfam | UniProtKB | Entrez-Gene | Ensembl Gene | NURSA