Myt1 Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor); WEE family
Cellular Component: 
Reference #:  Q95YJ1 (UniProtKB)
Alt. Names/Synonyms: kinase Myt1; Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; Myt1; MYT1 kinase; Myt1 protein; PKMYT1; PMYT1
Gene Symbols: Pkmyt1
Molecular weight: 62,570 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Select Structure to View Below

Myt1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB