eIF4G Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. 8 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; nucleus; polysome; postsynapse
Molecular Function:  ATP binding; eukaryotic initiation factor 4E binding; identical protein binding; molecular adaptor activity; mRNA binding; protein binding; RNA binding; translation factor activity, RNA binding; translation initiation factor activity; translation initiation factor binding
Biological Process:  behavioral fear response; cap-dependent translational initiation; cellular macromolecule biosynthetic process; cellular response to nutrient levels; developmental process; energy homeostasis; lung development; mitochondrion organization; negative regulation of autophagy; negative regulation of neuron death; negative regulation of peptidyl-threonine phosphorylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of cell death; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of eukaryotic translation initiation factor 4F complex assembly; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of miRNA mediated inhibition of translation; positive regulation of mRNA cap binding; positive regulation of neuron differentiation; positive regulation of peptidyl-serine phosphorylation; regulation of cellular response to stress; regulation of gene silencing by miRNA; regulation of mRNA stability; regulation of polysome binding; regulation of presynapse assembly; regulation of translational initiation; response to ethanol; translation; translational initiation; viral process
Reference #:  Q04637 (UniProtKB)
Alt. Names/Synonyms: DKFZp686A1451; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; EIF4-gamma; EIF4F; EIF4G; EIF4G1; EIF4GI; eucaryotic translation initiation factor 4G; Eukaryotic translation initiation factor 4 gamma 1; eukaryotic translation initiation factor 4 gamma, 1; IF4G1; p220; PARK18
Gene Symbols: EIF4G1
Molecular weight: 175,491 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein