DRD1 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Detected in caudate, nucleus accumbens and in the olfactory tubercle. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 17p14
Cellular Component:  axon; axon terminus; caveola; ciliary membrane; dendrite; dendritic shaft; dendritic spine; dendritic spine head; dendritic spine neck; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; GABA-ergic synapse; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; neuronal cell body; non-motile cilium; nucleus; plasma membrane
Molecular Function:  angiotensin receptor binding; ATPase binding; D3 dopamine receptor binding; dopamine binding; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gs; drug binding; G protein-coupled receptor activity; G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding; neurotransmitter receptor activity; protein binding; protein heterodimerization activity; protein phosphatase binding; protein-containing complex binding; signaling receptor binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adult walking behavior; associative learning; astrocyte development; behavioral fear response; behavioral response to cocaine; calcium-mediated signaling; cellular response to catecholamine stimulus; cellular response to dopamine; cellular response to hypoxia; cellular response to insulin stimulus; cerebral cortex GABAergic interneuron migration; chemical synaptic transmission; conditioned taste aversion; dentate gyrus development; dopamine receptor signaling pathway; dopamine transport; eating behavior; feeding behavior; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; glucose import; grooming behavior; habituation; hippocampus development; histone H3-S10 phosphorylation; intracellular protein transport; learning; locomotory behavior; long-term synaptic depression; long-term synaptic potentiation; maternal behavior; mating behavior; memory; modification of postsynaptic structure; muscle contraction; negative regulation of cell death; negative regulation of cell migration; negative regulation of circadian sleep/wake cycle, sleep; negative regulation of protein kinase activity; neuronal action potential; operant conditioning; orbitofrontal cortex development; peristalsis; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of feeding behavior; positive regulation of gene expression; positive regulation of long-term synaptic potentiation; positive regulation of membrane potential; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; postsynaptic modulation of chemical synaptic transmission; protein import into nucleus; regulation of dopamine metabolic process; regulation of ion transport; regulation of long-term neuronal synaptic plasticity; regulation of protein phosphorylation; regulation of synaptic vesicle exocytosis; regulation of vasoconstriction; response to activity; response to amino acid; response to amphetamine; response to cocaine; response to drug; response to estradiol; response to ethanol; response to food; response to morphine; response to nicotine; response to organic cyclic compound; response to organonitrogen compound; response to retinoic acid; response to steroid hormone; sensitization; social behavior; striatum development; synapse assembly; synaptic transmission, dopaminergic; temperature homeostasis; transmission of nerve impulse; vasodilation; visual learning
Reference #:  P18901 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; D1a; Dopamine D1 receptor; dopamine receptor 1A; dopamine receptor D1A; Dopamine-1A receptor; Drd-1; Drd1; Drd1a
Gene Symbols: Drd1
Molecular weight: 49,428 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below

DRD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene