DRD1 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Detected in caudate, nucleus accumbens and in the olfactory tubercle. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component:  ciliary membrane; cilium; dendritic spine; endoplasmic reticulum membrane; GABA-ergic synapse; glutamatergic synapse; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; non-motile cilium; nucleus; plasma membrane
Molecular Function:  dopamine binding; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gs; protein binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adult walking behavior; astrocyte development; behavioral fear response; behavioral response to cocaine; cellular response to catecholamine stimulus; cellular response to dopamine; cerebral cortex GABAergic interneuron migration; conditioned taste aversion; dentate gyrus development; dopamine metabolic process; dopamine transport; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; glucose import; grooming behavior; habituation; histone H3-S10 phosphorylation; long-term synaptic depression; long-term synaptic potentiation; maternal behavior; mating behavior; memory; neuronal action potential; operant conditioning; peristalsis; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of gene expression; positive regulation of potassium ion transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein import into nucleus; regulation of dopamine metabolic process; regulation of dopamine uptake involved in synaptic transmission; regulation of protein phosphorylation; regulation of synaptic vesicle exocytosis; response to amphetamine; response to drug; sensitization; striatum development; synapse assembly; synaptic transmission, dopaminergic; temperature homeostasis; transmission of nerve impulse; vasodilation; visual learning
Reference #:  P21728 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; DADR; Dopamine D1 receptor; dopamine receptor D1; DRD1; DRD1A
Gene Symbols: DRD1
Molecular weight: 49,293 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

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