DRD1 a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component:  ciliary membrane; cilium; dendritic spine; endoplasmic reticulum membrane; GABA-ergic synapse; glutamatergic synapse; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; non-motile cilium; nucleus; plasma membrane
Molecular Function:  dopamine binding; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gs; protein binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adult walking behavior; astrocyte development; behavioral fear response; behavioral response to cocaine; cellular response to catecholamine stimulus; cellular response to dopamine; cerebral cortex GABAergic interneuron migration; conditioned taste aversion; dentate gyrus development; dopamine metabolic process; dopamine transport; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; glucose import; grooming behavior; habituation; histone H3-S10 phosphorylation; long-term synaptic depression; long-term synaptic potentiation; maternal behavior; mating behavior; memory; neuronal action potential; operant conditioning; peristalsis; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of gene expression; positive regulation of potassium ion transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein import into nucleus; regulation of dopamine metabolic process; regulation of dopamine uptake involved in synaptic transmission; regulation of protein phosphorylation; regulation of synaptic vesicle exocytosis; response to amphetamine; response to drug; sensitization; striatum development; synapse assembly; synaptic transmission, dopaminergic; temperature homeostasis; transmission of nerve impulse; vasodilation; visual learning
Reference #:  P21728 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; DADR; Dopamine D1 receptor; dopamine receptor D1; DRD1; DRD1A
Gene Symbols: DRD1
Molecular weight: 49,293 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
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Protein Structure Not Found.

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