DRD1 a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane; integral component of plasma membrane; nucleus; plasma membrane
Molecular Function:  dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity; G-protein alpha-subunit binding; protein binding
Biological Process:  adenylate cyclase activation; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adult walking behavior; astrocyte development; behavioral fear response; behavioral response to cocaine; cellular response to catecholamine stimulus; cerebral cortex GABAergic interneuron migration; conditioned taste aversion; dentate gyrus development; dopamine metabolic process; dopamine transport; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; generation of action potential; glucose import; grooming behavior; habituation; maternal behavior; mating behavior; memory; operant conditioning; peristalsis; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of cell migration; positive regulation of gene expression; positive regulation of potassium ion transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein import into nucleus; regulation of dopamine metabolic process; regulation of dopamine uptake; regulation of protein amino acid phosphorylation; response to amphetamine; response to drug; sensitization; striatum development; synaptic transmission, dopaminergic; synaptogenesis; thermoregulation; transmission of nerve impulse; vasodilation; visual learning
Reference #:  P21728 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; DADR; Dopamine D1 receptor; dopamine receptor D1; DRD1; DRD1A
Gene Symbols: DRD1
Molecular weight: 49,293 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
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Protein Structure Not Found.

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