MARCKS MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. Belongs to the MARCKS family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 20q12
Cellular Component:  actin filament bundle; axon terminus; bleb; cell cortex; centrosome; chromatoid body; cytoplasm; dendritic branch; dendritic spine; germinal vesicle; glutamatergic synapse; growth cone; membrane; microtubule; organelle; outer dense fiber; plasma membrane; postsynaptic cytoskeleton; postsynaptic membrane; presynaptic cytosol; presynaptic membrane
Molecular Function:  actin filament binding; calmodulin binding; identical protein binding; phosphatidylserine binding; phospholipid binding; protein kinase C binding
Biological Process:  actin crosslink formation; actin filament bundle assembly; actin filament organization; activation of phospholipase D activity; apoptotic process; cell-substrate adhesion; central nervous system development; intracellular protein transport; mitochondrion organization; neural tube development; neurogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of insulin receptor signaling pathway; positive regulation of neuron projection development; positive regulation of protein kinase C activity; regulation of modification of postsynaptic actin cytoskeleton; response to endoplasmic reticulum stress; ventricular cardiac muscle tissue development
Reference #:  P30009 (UniProtKB)
Alt. Names/Synonyms: KINC; Macs; MARCKS; myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich protein kinase C substrate; Protein kinase C substrate 80 kDa protein
Gene Symbols: Marcks
Molecular weight: 29,795 Da
Basal Isoelectric point: 4.32  Predict pI for various phosphorylation states
CST Pathways:  Protein Kinase C Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene