ATF-2 Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. Belongs to the bZIP family. ATF subfamily. Ubiquitously expressed, with more abundant expression in the brain. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; EC; Transcription factor
Chromosomal Location of Human Ortholog: 3q23
Cellular Component:  cytoplasm; membrane; mitochondrial outer membrane; nucleoplasm; nucleus; site of double-strand break
Molecular Function:  cAMP response element binding; cAMP response element binding protein binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; enhancer sequence-specific DNA binding; histone acetyltransferase activity; metal ion binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II activating transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  adipose tissue development; amelogenesis; cellular response to DNA damage stimulus; fat cell differentiation; histone acetylation; intra-S DNA damage checkpoint; negative regulation of angiogenesis; negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; outflow tract morphogenesis; positive regulation of cardiac muscle myoblast proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of mitochondrial membrane permeability involved in apoptotic process; positive regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta2 production; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to osmotic stress; response to water deprivation
Reference #:  Q00969 (UniProtKB)
Alt. Names/Synonyms: Activating transcription factor 2; ATF-2; Atf2; cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2; Cyclic AMP-dependent transcription factor ATF-2
Gene Symbols: Atf2
Molecular weight: 52,287 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene