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JNK3 iso2
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; EC 2.7.11.24; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 4q21.3 |
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Cellular Component:
cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
ATP binding; JUN kinase activity; MAP kinase kinase activity; protein binding; protein serine kinase activity
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Biological Process:
cellular senescence; Fc-epsilon receptor signaling pathway; JNK cascade; protein phosphorylation; regulation of circadian rhythm; regulation of DNA-binding transcription factor activity; response to light stimulus; rhythmic process; signal transduction
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Disease: Macrocephaly And Epileptic Encephalopathy
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Reference #:
P53779-2
(UniProtKB)
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Alt. Names/Synonyms: c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK3; JNK3 alpha protein kinase; JNK3 iso2; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; MGC50974; Mitogen-activated protein kinase 10; MK10; p493F12; p54bSAPK; PRKM10; SAPK1B; stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3
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Gene Symbols: MAPK10
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Molecular weight:
48,554 Da
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Basal Isoelectric point:
7.57
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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Death Receptor Signaling
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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NF-kB Signaling
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Parkinson's Disease
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-Like Receptor Signaling
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