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ULK4
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family; ULK subfamily |
| Chromosomal Location of rat Ortholog: 8q32 |
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Cellular Component:
extracellular region
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Molecular Function:
ATP binding; protein kinase activity
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Biological Process:
adult behavior; axoneme assembly; brain development; central nervous system myelination; cerebrospinal fluid circulation; ciliary basal body organization; corpus callosum development; epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; GABAergic neuron differentiation; gene expression; microtubule cytoskeleton organization; motile cilium assembly; neurogenesis; neuroinflammatory response; neuronal stem cell division; protein phosphorylation; regulation of JNK cascade; regulation of MAPK cascade; regulation of neuron migration; regulation of neuron projection development; regulation of p38MAPK cascade; regulation of protein kinase C signaling; social behavior; ventricular system development
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Reference #:
M0R685
(UniProtKB)
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Alt. Names/Synonyms: RGD1565726; Ulk4; unc-51 like kinase 4; Unc-51-like kinase 4
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Gene Symbols: Ulk4
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Molecular weight:
141,391 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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