FGD5 Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. Expressed in endothelial cells (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 4q34
Cellular Component: 
Molecular Function:  metal ion binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  regulation of Rho protein signal transduction
Reference #:  F1LTE6 (UniProtKB)
Alt. Names/Synonyms: Fgd5; FYVE, RhoGEF and PH domain containing 5; FYVE, RhoGEF and PH domain-containing 5
Gene Symbols: Fgd5
Molecular weight: 149,564 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein