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RELB
a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. Stimulates promoter activity in the presence of isoform 3 of NFKB2. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Is required for both T and B lymphocyte maturation and function. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of rat Ortholog: 1q21 |
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Cellular Component:
centrosome; chromatin; cytosol; nucleoplasm; nucleus; protein-containing complex; synapse; transcription repressor complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
antigen processing and presentation; cellular response to osmotic stress; cellular response to stress; circadian regulation of gene expression; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; lymphocyte differentiation; myeloid dendritic cell differentiation; negative regulation of DNA-templated transcription; negative regulation of interferon-beta production; NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; response to cytokine; T-helper 1 cell differentiation; T-helper 1 type immune response
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Reference #:
D4A8H1
(UniProtKB)
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Alt. Names/Synonyms: Relb; RELB proto-oncogene, NF-kB subunit; v-rel avian reticuloendotheliosis viral oncogene homolog B
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Gene Symbols: Relb
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Molecular weight:
60,173 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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