EFNB1 Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638). Note: This description may include information from UniProtKB.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Cellular Component:  cytosol; integral component of membrane; plasma membrane
Molecular Function:  ephrin receptor binding
Biological Process:  axon guidance; ephrin receptor signaling pathway
Reference #:  O73612 (UniProtKB)
Alt. Names/Synonyms: CEK5 ligand; CEK5 receptor ligand; CEK5-L; CEL5-L; EFL-3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin-B1; Ephrin-B1 precursor; EPL2; EPLG2; kinase ephrin-B1; LERK-2; LERK2; STRA1; STRA1 protein
Gene Symbols: EFNB1
Molecular weight: 36,859 Da
Basal Isoelectric point: 9.05  Predict pI for various phosphorylation states
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EFNB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene