ATF-1 a transcription factor that is a member of the leucine zipper family. Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Binds the Tax-responsive element (TRE) of HTLV-I. Activated downstream of IL-1. c-Src and TRAF6 are mediators of IL-1-induced AP-1 activation. Plays an important role in the trans-activation of the MHC class II trans-activator (CIITA) promoter III in B cells. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  ATF1-ATF4 transcription factor complex; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein heterodimerization activity; protein-containing complex binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  cellular protein-containing complex assembly; positive regulation of DNA replication; positive regulation of neuron projection development; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P81269 (UniProtKB)
Alt. Names/Synonyms: Activating transcription factor 1; Atf1; cAMP-dependent transcription factor ATF-1; Cyclic AMP-dependent transcription factor ATF-1; TCR-ATF1
Gene Symbols: Atf1
Molecular weight: 29,238 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Parkinson's Disease  |  Regulation of P38 MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene