Destrin Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 G1|2 70.89 cM
Cellular Component:  actin cytoskeleton; cortical actin cytoskeleton; cytoplasm
Molecular Function:  actin binding; actin filament binding
Biological Process:  actin filament depolymerization; actin filament fragmentation; actin filament severing; positive regulation of actin filament depolymerization
Reference #:  Q9R0P5 (UniProtKB)
Alt. Names/Synonyms: 2610043P17Rik; Actin-depolymerizing factor; ADF; AU042046; corn1; corneal disease 1; DEST; Destrin; Dsn; Dstn; OTTMUSP00000003185; sid; Sid 23; Sid23; sid23p
Gene Symbols: Dstn
Molecular weight: 18,522 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene