Destrin Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 20p12.1
Cellular Component:  actin cytoskeleton; cortical actin cytoskeleton; cytoplasm
Molecular Function:  actin filament binding; protein binding
Biological Process:  actin filament depolymerization; actin filament fragmentation; actin filament severing; actin polymerization or depolymerization; positive regulation of actin filament depolymerization
Reference #:  P60981 (UniProtKB)
Alt. Names/Synonyms: ACTDP; Actin-depolymerizing factor; ADF; bA462D18.2; bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)); DEST; Destrin; destrin (actin depolymerizing factor); destrin, actin depolymerizing factor; DSN; DSTN; epididymis luminal protein 32; epididymis secretory sperm binding protein; HEL32
Gene Symbols: DSTN
Molecular weight: 18,506 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein