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Destrin
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 20p12.1 |
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Cellular Component:
actin cytoskeleton; cortical actin cytoskeleton; cytoplasm
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Molecular Function:
actin filament binding; protein binding
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Biological Process:
actin filament depolymerization; actin filament fragmentation; actin filament severing; actin polymerization or depolymerization; positive regulation of actin filament depolymerization
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Reference #:
P60981
(UniProtKB)
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Alt. Names/Synonyms: ACTDP; Actin-depolymerizing factor; ADF; bA462D18.2; bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)); DEST; Destrin; destrin (actin depolymerizing factor); destrin, actin depolymerizing factor; DSN; DSTN; epididymis luminal protein 32; epididymis secretory sperm binding protein; HEL32
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Gene Symbols: DSTN
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Molecular weight:
18,506 Da
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Basal Isoelectric point:
8.06
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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