Destrin Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Cellular Component:  actin cytoskeleton
Molecular Function:  actin filament binding
Biological Process:  actin filament depolymerization; actin filament severing; positive regulation of actin filament depolymerization
Reference #:  P18359 (UniProtKB)
Alt. Names/Synonyms: ACTDP; Actin-depolymerizing factor; ADF; DEST; Destrin; destrin, actin depolymerizing factor; DSN; DSTN; SID23
Gene Symbols: DSTN
Molecular weight: 18,533 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Destrin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene