CDC34 a member of the ubiquitin-conjugating enzyme family. Is a part of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for ubiquitin-mediated degradation of cell cycle G1 regulators. Required for the initiation of DNA replication. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  cytoplasm; cytosol; nuclear speck; nucleus
Molecular Function:  ATP binding; nucleotide binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  cell cycle; cellular response to interferon-beta; negative regulation of cAMP-mediated signaling; positive regulation of inclusion body assembly; positive regulation of neuron apoptotic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  Q8CFI2 (UniProtKB)
Alt. Names/Synonyms: AI327276; Cdc34; cell division cycle 34 homolog (S. cerevisiae); E2-CDC34; UB2R1; Ube2r1; ubiquitin-conjugating enzyme Cdc34; Ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Gene Symbols: Cdc34
Molecular weight: 26,622 Da
Basal Isoelectric point: 4.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein