CDC5L
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Belongs to the CEF1 family. Ubiquitously expressed in both fetal and adult tissues. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor |
Chromosomal Location of mouse Ortholog: 17|17 B3 |
Cellular Component:
catalytic step 2 spliceosome; cytoplasm; DNA replication factor A complex; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-DNA complex; Prp19 complex; spliceosomal complex; U2-type catalytic step 2 spliceosome
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; leucine zipper domain binding; protein kinase binding; protein phosphatase 1 binding; RNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor binding; WD40-repeat domain binding
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Biological Process:
cell cycle; cellular response to nerve growth factor stimulus; cellular response to wortmannin; DNA damage checkpoint signaling; DNA damage response; DNA repair; mRNA processing; mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; RNA splicing
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Reference #:
Q6A068
(UniProtKB)
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Alt. Names/Synonyms: 1200002I02Rik; AA408004; Cdc5-like protein; Cdc5l; cell division cycle 5-like (S. pombe); Cell division cycle 5-like protein; Cell division cycle 5-related protein; Kiaa0432; PCDC; PCDC5RP
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Gene Symbols: Cdc5l
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Molecular weight:
92,190 Da
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Basal Isoelectric point:
7.98
Predict pI for various phosphorylation states
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