CDC5L DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Belongs to the CEF1 family. Ubiquitously expressed in both fetal and adult tissues. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor
Chromosomal Location of Human Ortholog: 17|17 B3
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-DNA complex; Prp19 complex; spliceosomal complex; U2-type catalytic step 2 spliceosome
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; leucine zipper domain binding; protein kinase binding; protein phosphatase 1 binding; RNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor binding; WD40-repeat domain binding
Biological Process:  cell cycle; cellular response to DNA damage stimulus; cellular response to nerve growth factor stimulus; cellular response to wortmannin; DNA repair; mitotic cell cycle; mRNA processing; mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; RNA splicing; signal transduction involved in DNA damage checkpoint
Reference #:  Q6A068 (UniProtKB)
Alt. Names/Synonyms: 1200002I02Rik; AA408004; Cdc5-like protein; Cdc5l; cell division cycle 5-like (S. pombe); Cell division cycle 5-like protein; Cell division cycle 5-related protein; Kiaa0432; PCDC5RP
Gene Symbols: Cdc5l
Molecular weight: 92,190 Da
Basal Isoelectric point: 7.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene