OSR1 oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB. Note: This description may include information from UniProtKB.
Protein type: EC; FRAY subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 9|9 F3
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; cellular hypotonic response; cellular response to chemokine; chemokine (C-C motif) ligand 21 signaling pathway; chemokine (C-X-C motif) ligand 12 signaling pathway; intracellular signal transduction; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; osmosensory signaling pathway; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of T cell chemotaxis; protein autophosphorylation; protein phosphorylation; response to oxidative stress; signal transduction by protein phosphorylation; signal transduction by trans-phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q6P9R2 (UniProtKB)
Alt. Names/Synonyms: 2210022N24Rik; 2810422B09Rik; AI462649; AW209236; mKIAA1101; Osr1; Oxidative stress-responsive 1 protein; oxidative-stress responsive 1; Oxsr1; Serine/threonine-protein kinase OSR1
Gene Symbols: Oxsr1
Molecular weight: 58,214 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene