OSBPL8 Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. Belongs to the OSBP family. Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10|10 D1
Cellular Component:  cortical endoplasmic reticulum; cytosol; endoplasmic reticulum; integral component of membrane; intracellular membrane-bounded organelle; membrane; nuclear membrane; nucleus
Molecular Function:  cholesterol binding; lipid binding; phosphatidylinositol-4-phosphate binding; phosphatidylserine binding; phospholipid transporter activity; protein binding; sterol binding; sterol transporter activity
Biological Process:  activation of protein kinase B activity; fat cell differentiation; lipid transport; negative regulation of cell migration; negative regulation of sequestering of triglyceride; phospholipid transport; positive regulation of glucose import; positive regulation of insulin receptor signaling pathway; positive regulation of protein kinase B signaling; protein localization to nuclear pore
Reference #:  B9EJ86 (UniProtKB)
Alt. Names/Synonyms: AA536976; AA536995; C730029P18Rik; D330025H14Rik; mKIAA1451; ORP-8; Osbpl8; oxysterol binding protein-like 8; Oxysterol-binding protein; oxysterol-binding protein-like protein 8; Oxysterol-binding protein-related protein 8
Gene Symbols: Osbpl8
Molecular weight: 101,269 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below

OSBPL8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein