OSBPL11 Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Belongs to the OSBP family. Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956). Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 16|16 B3
Cellular Component:  cytosol; endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; nucleoplasm
Molecular Function:  lipid binding; sterol binding; sterol transporter activity
Biological Process:  fat cell differentiation; lipid transport; positive regulation of sequestering of triglyceride
Reference #:  Q8CI95 (UniProtKB)
Alt. Names/Synonyms: 9430097N02Rik; AI132306; AU019795; ORP-11; OSB11; OSBP-related protein 11; Osbpl11; oxysterol binding protein-like 11; Oxysterol-binding protein-related protein 11
Gene Symbols: Osbpl11
Molecular weight: 83,629 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
Select Structure to View Below

OSBPL11

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene