PXN Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component:  adherens junction; cell cortex; cytosol; focal adhesion; lamellipodium; microtubule associated complex; plasma membrane; stress fiber
Molecular Function:  beta-catenin binding; integrin binding; metal ion binding; neuropilin binding; protein binding; protein kinase binding; protein phosphatase binding; ubiquitin protein ligase binding; vinculin binding
Biological Process:  cell adhesion; cell-matrix adhesion; cellular response to reactive oxygen species; endothelial cell migration; growth hormone receptor signaling pathway; muscle contraction; positive regulation of stress fiber assembly; signal complex assembly; signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P49023 (UniProtKB)
Alt. Names/Synonyms: FLJ16691; PAXI; Paxillin; PXN; testicular tissue protein Li 134
Gene Symbols: PXN
Molecular weight: 64,505 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PXN

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein