CSDA Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression. Highly expressed in skeletal muscle and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q42
Cellular Component:  cytoplasm; cytosol; gap junction; nucleus
Molecular Function:  DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; mRNA 3'-UTR binding; nucleic acid binding; polysome binding; RNA polymerase II regulatory region sequence-specific DNA binding; single-stranded DNA binding
Biological Process:  animal organ regeneration; cellular hyperosmotic response; cellular response to tumor necrosis factor; fertilization; in utero embryonic development; male gonad development; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; negative regulation of necroptotic process; negative regulation of skeletal muscle tissue development; negative regulation of transcription by RNA polymerase II; positive regulation of organ growth; spermatogenesis
Reference #:  Q62764 (UniProtKB)
Alt. Names/Synonyms: cold shock domain protein A; Cold shock domain-containing protein A; Csda; Dbpa; DNA-binding protein A; MGC124554; Muscle Y-box protein YB2; NF-GMB; RYB-A; Y-box-binding protein 3; Y-box-binding protein A; Yb2
Gene Symbols: Csda
Molecular weight: 38,852 Da
Basal Isoelectric point: 9.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene