MTA1 metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6q32
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; Golgi apparatus; intracellular membrane-bounded organelle; microtubule; nuclear envelope; nucleoplasm; nucleus; NuRD complex; rough endoplasmic reticulum
Molecular Function:  chromatin binding; enzyme binding; histone deacetylase binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; zinc ion binding
Biological Process:  circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; female pregnancy; histone deacetylation; locomotor rhythm; negative regulation of nucleic acid-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription; positive regulation of protein autoubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; response to ionizing radiation; secretory granule organization
Reference #:  Q62599 (UniProtKB)
Alt. Names/Synonyms: metastasis associated 1; Metastasis-associated protein MTA1; Mta1; Zg29
Gene Symbols: Mta1
Molecular weight: 79,412 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MTA1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene