MRE11A Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Belongs to the MRE11/RAD32 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease
Chromosomal Location of mouse Ortholog: 9|9 A2
Cellular Component:  BRCA1-C complex; chromatin; chromosomal region; chromosome; chromosome, telomeric region; condensed nuclear chromosome; cytoplasm; Mre11 complex; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; replication fork; site of double-strand break
Molecular Function:  3'-5' exonuclease activity; 3'-5'-exodeoxyribonuclease activity; 5'-3' exonuclease activity; DNA binding; DNA helicase activity; endodeoxyribonuclease activity; endonuclease activity; exonuclease activity; hydrolase activity; identical protein binding; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA endodeoxyribonuclease activity
Biological Process:  cell population proliferation; cellular response to DNA damage stimulus; chromosome organization; DNA double-strand break processing; DNA duplex unwinding; DNA repair; DNA strand resection involved in replication fork processing; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; homologous chromosome pairing at meiosis; homologous recombination; meiotic cell cycle; meiotic DNA double-strand break formation; mitochondrial double-strand break repair via homologous recombination; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; mitotic intra-S DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of viral entry into host cell; positive regulation of kinase activity; positive regulation of protein autophosphorylation; positive regulation of telomere maintenance; sister chromatid cohesion; telomere maintenance; telomeric 3' overhang formation
Reference #:  Q61216 (UniProtKB)
Alt. Names/Synonyms: Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; meiotic recombination 11 homolog A (S. cerevisiae); MmMRE11A; Mre11; MRE11 homolog 1; MRE11 homolog A; Mre11a; MRE11A homolog A, double strand break repair nuclease; Mre11b
Gene Symbols: Mre11a
Molecular weight: 80,223 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene