EIF2D Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P- site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Belongs to the eIF2D family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 1 E4|1 56.9 cM
Cellular Component:  cytoplasm; cytosol; nuclear body
Molecular Function:  RNA binding; translation initiation factor activity
Biological Process:  formation of translation preinitiation complex; IRES-dependent viral translational initiation; ribosome disassembly; translation; translational initiation
Reference #:  Q61211 (UniProtKB)
Alt. Names/Synonyms: D1Ertd5e; Eukaryotic translation initiation factor 2D; Lgtn; LIGA; Ligatin; OTTMUSP00000024012
Gene Symbols: Lgtn
Molecular weight: 62,830 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
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EIF2D

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene