SUZ12 Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. Overexpressed in breast and colon cancer. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11 B5|11 47.36 cM
Cellular Component:  chromosome; ESC/E(Z) complex; nuclear body; nucleolus; nucleus; protein-DNA complex; RSC-type complex; sex chromatin
Molecular Function:  chromatin binding; chromatin DNA binding; histone methyltransferase activity; metal ion binding; methylated histone binding; promoter-specific chromatin binding; protein binding; RNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  chromatin organization; histone H3-K27 trimethylation; histone methylation; histone ubiquitination; negative regulation of cell differentiation; negative regulation of chemokine production; negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of tyrosine phosphorylation of STAT protein; positive regulation of cell proliferation
Reference #:  Q80U70 (UniProtKB)
Alt. Names/Synonyms: 2610028O16Rik; AI195385; AU016842; AW536442; D11Ertd530; D11Ertd530e; Kiaa0160; mKIAA0160; OTTMUSP00000000248; Polycomb protein Suz12; suppressor of zeste 12 homolog; suppressor of zeste 12 homolog (Drosophila); Suppressor of zeste 12 protein homolog; Suz12; SUZ12 polycomb repressive complex 2 subunit
Gene Symbols: Suz12
Molecular weight: 83,026 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SUZ12

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene