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PCDH24
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells. Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers (PubMed:12117771, PubMed:15534908). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409). Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 5q35.2 |
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Cellular Component:
anchoring junction; apical plasma membrane; brush border; brush border membrane; microvillus membrane; plasma membrane
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Molecular Function:
calcium ion binding; cell adhesion molecule binding; protein binding
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Biological Process:
cell-cell adhesion; cell-cell adhesion mediated by cadherin; epithelial cell differentiation; homophilic cell adhesion via plasma membrane adhesion molecules; intermicrovillar adhesion; negative regulation of cell growth involved in contact inhibition; regulation of microvillus length
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Reference #:
Q9BYE9
(UniProtKB)
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Alt. Names/Synonyms: cadherin related family member 2; Cadherin-related family member 2; CDHR2; FLJ20124; FLJ20383; MGC163154; PC-LKC; PCDH24; PCLKC; protocadherin 24; Protocadherin LKC; Protocadherin-24
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Gene Symbols: CDHR2
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Molecular weight:
141,543 Da
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Basal Isoelectric point:
4.31
Predict pI for various phosphorylation states
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