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TINAGL1
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. Belongs to the peptidase C1 family. Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 1p35.2 |
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Cellular Component:
cytoplasm; extracellular region; extracellular space; lysosome
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Molecular Function:
cysteine-type peptidase activity; extracellular matrix structural constituent; laminin binding; protein binding
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Biological Process:
endosomal transport; proteolysis
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Reference #:
Q9GZM7
(UniProtKB)
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Alt. Names/Synonyms: androgen-regulated gene 1; ARG1; GIS5; Glucocorticoid-inducible protein 5; LCN7; LIECG3; lipocalin 7; OLRG-2; OLRG2; Oxidized LDL-responsive gene 2 protein; oxidized-LDL responsive gene 2; P3ECSL; TIN Ag-related protein; TIN-Ag-RP; TINAG-like 1; TINAGL; TINAGL1; TINAGRP; TINAL; tubulointerstitial nephritis antigen like 1; Tubulointerstitial nephritis antigen-like; tubulointerstitial nephritis antigen-like 1; Tubulointerstitial nephritis antigen-related protein
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Gene Symbols: TINAGL1
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Molecular weight:
52,387 Da
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Basal Isoelectric point:
6.54
Predict pI for various phosphorylation states
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