GCSFR Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Belongs to the type I cytokine receptor family. Type 2 subfamily. One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 4 D2.2|4 59.77 cM
Cellular Component:  external side of plasma membrane; integral component of membrane; membrane; receptor complex
Molecular Function:  cytokine binding; cytokine receptor activity; granulocyte colony-stimulating factor binding; interleukin-3 binding; interleukin-3 receptor activity; protein binding
Biological Process:  cell adhesion; neutrophil chemotaxis; regulation of myeloid cell differentiation
Reference #:  P40223 (UniProtKB)
Alt. Names/Synonyms: Cd114; colony stimulating factor 3 receptor (granulocyte); Csf3r; Csfgr; G-CSF receptor; G-CSF-R; G-CSFR; GCSFR; Granulocyte colony-stimulating factor receptor; MGC141472; MGC141473; OTTMUSP00000009665
Gene Symbols: Csf3r
Molecular weight: 93,379 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
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GCSFR

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene