Plectin-1 Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Belongs to the plakin or cytolinker family. Widely expressed with highest levels in muscle, heart, placenta and spinal cord. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  brush border; costamere; cytosol; focal adhesion; hemidesmosome; intermediate filament cytoskeleton; plasma membrane; sarcolemma; sarcoplasm
Molecular Function:  actin binding; ankyrin binding; protein binding
Biological Process:  hemidesmosome assembly
Reference #:  Q15149 (UniProtKB)
Alt. Names/Synonyms: EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; PLEC; PLEC1; PLEC1b; Plectin; plectin 1, intermediate filament binding protein 500kDa; Plectin-1; PLTN
Gene Symbols: PLEC
Molecular weight: 531,791 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein