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Diminuto
Catalyzes the reduction of the Delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 4|4 C7 |
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Cellular Component:
cytoplasm; endoplasmic reticulum; Golgi apparatus; nucleus
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Molecular Function:
delta24(24-1) sterol reductase activity; delta24-sterol reductase activity; enzyme binding; FAD binding; flavin adenine dinucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; peptide antigen binding
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Biological Process:
amyloid precursor protein catabolic process; cholesterol biosynthetic process; cholesterol biosynthetic process via desmosterol; cholesterol metabolic process; lipid metabolic process; male genitalia development; membrane organization; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; plasminogen activation; protein localization; Ras protein signal transduction; skin development; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process; sterol metabolic process; tissue development
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Reference #:
Q8VCH6
(UniProtKB)
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Alt. Names/Synonyms: 2310076D10Rik; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase; 5830417J06Rik; Delta(24)-sterol reductase; DHC24; Dhcr24; Diminuto; Kiaa0018; mKIAA0018; OTTMUSP00000008616; sela; seladin-1
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Gene Symbols: Dhcr24
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Molecular weight:
60,112 Da
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Basal Isoelectric point:
8.42
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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