CLIM1 Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts. Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1q54
Cellular Component:  cell-cell adherens junction; cytoskeleton; filamentous actin; stress fiber; transcription factor complex; Z disc
Molecular Function:  actin binding; metal ion binding; muscle alpha-actinin binding; protein binding; transcription coactivator activity
Biological Process:  actin cytoskeleton organization; heart development; muscle structure development; positive regulation of nucleic acid-templated transcription; regulation of transcription, DNA-templated; response to hypoxia
Reference #:  P52944 (UniProtKB)
Alt. Names/Synonyms: C-terminal LIM domain protein 1; Clim1; Clp36; Elfin; LIM domain protein CLP-36; LIM protein; Pdlim1; PDZ and LIM domain 1; PDZ and LIM domain protein 1
Gene Symbols: Pdlim1
Molecular weight: 35,584 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene