PKHF1 May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 7|7 B3
Cellular Component:  cytoplasm; early endosome; endosome; lysosome; mitochondrion; nucleus
Molecular Function:  metal ion binding; phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding
Biological Process:  apoptotic process; endosome organization; endosome to lysosome transport; positive regulation of autophagy; positive regulation of intrinsic apoptotic signaling pathway; protein localization to plasma membrane; regulation of mitochondrial membrane permeability; vesicle organization
Reference #:  Q3TB82 (UniProtKB)
Alt. Names/Synonyms: 1810013P09Rik; APPD; Lapf; Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; PH domain-containing family F member 1; PHAFIN1; PKHF1; pleckstrin homology domain containing, family F (with FYVE domain) member 1; Pleckstrin homology domain-containing family F member 1; Plekhf1; ZFYVE15
Gene Symbols: Plekhf1
Molecular weight: 31,158 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Select Structure to View Below

PKHF1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein