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PKHF1
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 19q12 |
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Cellular Component:
early endosome; endosome; endosome membrane; lysosomal membrane; lysosome; nucleus; perinuclear region of cytoplasm
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Molecular Function:
metal ion binding; phosphatidylinositol binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding
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Biological Process:
apoptotic process; endosome organization; endosome to lysosome transport; positive regulation of autophagy; positive regulation of intrinsic apoptotic signaling pathway; protein localization to plasma membrane; vesicle organization
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Reference #:
Q96S99
(UniProtKB)
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Alt. Names/Synonyms: Apoptosis-inducing protein; apoptosis-inducing protein D; APPD; LAPF; Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; MGC4090; PH and FYVE domain-containing protein 1; PH domain-containing family F member 1; phafin 1; Phafin-1; PHAFIN1; PKHF1; pleckstrin homology and FYVE domain containing 1; pleckstrin homology domain containing, family F (with FYVE domain) member 1; Pleckstrin homology domain-containing family F member 1; PLEKHF1; ZFYVE15; Zinc finger FYVE domain-containing protein 15
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Gene Symbols: PLEKHF1
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Molecular weight:
31,195 Da
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Basal Isoelectric point:
8.59
Predict pI for various phosphorylation states
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