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PXN iso3
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 12q24.23 |
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Cellular Component:
cell cortex; cell-cell junction; cytosol; focal adhesion; lamellipodium; microtubule associated complex; plasma membrane; stress fiber
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Molecular Function:
beta-catenin binding; metal ion binding; neuropilin binding; protein binding; protein phosphatase binding; vinculin binding
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Biological Process:
cell adhesion; cell migration; cellular response to reactive oxygen species; endothelial cell migration; growth hormone receptor signaling pathway; positive regulation of stress fiber assembly; signal complex assembly; signal transduction; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway
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Reference #:
P49023-3
(UniProtKB)
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Alt. Names/Synonyms: FLJ16691; PAXI; Paxillin; PXN; PXN iso3; testicular tissue protein Li 134
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Gene Symbols: PXN
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Molecular weight:
66,212 Da
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Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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