CTSK Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Belongs to the peptidase C1 family. Predominantly expressed in osteoclasts (bones). Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.38; Protease
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  endolysosome lumen; extracellular region; extracellular space; intracellular membrane-bounded organelle; lysosomal lumen; lysosome; nucleoplasm
Molecular Function:  collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; protein binding; proteoglycan binding
Biological Process:  bone resorption; collagen catabolic process; extracellular matrix disassembly; intramembranous ossification; negative regulation of cartilage development; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of keratinocyte differentiation; toll-like receptor signaling pathway
Disease: Pycnodysostosis
Reference #:  P43235 (UniProtKB)
Alt. Names/Synonyms: Cathepsin K; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin X; CATK; CTS02; CTSK; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD
Gene Symbols: CTSK
Molecular weight: 36,966 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below

CTSK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene