Rab7 Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan. Belongs to the small GTPase superfamily. Rab family. Widely expressed; high expression found in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 4q34
Cellular Component:  alveolar lamellar body; anchored component of synaptic vesicle membrane; autophagosome membrane; cytoplasm; cytoplasmic vesicle; cytosol; endosome; endosome membrane; exocytic vesicle; extrinsic component of lysosome membrane; Golgi apparatus; late endosome; late endosome membrane; lipid droplet; lysosome; melanosome membrane; phagocytic vesicle; phagocytic vesicle membrane; phagophore assembly site membrane; vacuolar membrane
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein binding; Rac GTPase binding; retromer complex binding
Biological Process:  autophagosome assembly; bone resorption; early endosome to late endosome transport; endosome to lysosome transport; epidermal growth factor catabolic process; intracellular protein transport; lipid catabolic process; lipophagy; negative regulation of exosomal secretion; phagosome acidification; phagosome-lysosome fusion; positive regulation of exosomal secretion; positive regulation of protein catabolic process; positive regulation of viral process; protein targeting to lysosome; protein to membrane docking; Rab protein signal transduction; retrograde transport, endosome to Golgi; viral release from host cell
Reference #:  P09527 (UniProtKB)
Alt. Names/Synonyms: Rab7; RAB7, member RAS oncogene family; Rab7a; RAB7A, member RAS oncogene family; Ras-related protein BRL-RAS; Ras-related protein p23; Ras-related protein Rab-7a
Gene Symbols: Rab7a
Molecular weight: 23,504 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene