anillin
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration. Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Actin-binding; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 7p14.2 |
Cellular Component:
actin cytoskeleton; actomyosin contractile ring; bleb; cell cortex; cytosol; midbody; nucleoplasm
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Molecular Function:
actin binding
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Biological Process:
actomyosin contractile ring assembly; hematopoietic progenitor cell differentiation; mitotic cytokinesis; podocyte cell migration; positive regulation of bleb assembly; regulation of exit from mitosis; septin ring assembly; septin ring organization
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Disease: Focal Segmental Glomerulosclerosis 8
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Reference #:
Q9NQW6
(UniProtKB)
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Alt. Names/Synonyms: Actin-binding protein anillin; Anillin; anillin actin binding protein; anillin, actin binding protein; ANLN; DKFZp779A055; FSGS8; scra; Scraps
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Gene Symbols: ANLN
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Molecular weight:
124,199 Da
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Basal Isoelectric point:
8.38
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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