PDLIM5 May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses. Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q44
Cellular Component:  actin cytoskeleton; cell junction; cell-cell adherens junction; cytosol; filamentous actin; membrane; neuron projection; postsynaptic density; postsynaptic membrane; stress fiber; Z disc
Molecular Function:  actin binding; actinin binding; metal ion binding; muscle alpha-actinin binding; protein binding; protein kinase C binding; protein N-terminus binding; receptor signaling complex scaffold activity
Biological Process:  actin cytoskeleton organization; cell growth involved in cardiac muscle cell development; heart development; muscle structure development; positive regulation of signal transduction; regulation of dendritic spine morphogenesis; regulation of synapse assembly
Reference #:  Q62920 (UniProtKB)
Alt. Names/Synonyms: Enh; Enh1; Enigma homolog; Enigma-like PDZ and LIM domains protein; PDLI5; Pdlim5; PDZ and LIM domain 5; PDZ and LIM domain protein 5
Gene Symbols: Pdlim5
Molecular weight: 63,201 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene