NIPA Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6|6 A3.3
Cellular Component:  nuclear membrane; nucleus
Molecular Function:  metal ion binding; protein binding; protein kinase binding; zinc ion binding
Biological Process:  cell cycle; cell division; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Reference #:  Q80YV2 (UniProtKB)
Alt. Names/Synonyms: 1110054L24Rik; AU018540; AU019789; HSPC216; mNIPA; Nipa; nuclear interacting partner of ALK; nuclear interacting partner of anaplastic lymphoma kinase (Alk); Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; OTTMUSP00000015182; Zc3hc1; Zinc finger C3HC-type protein 1; zinc finger, C3HC type 1
Gene Symbols: Zc3hc1
Molecular weight: 55,196 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene