SKAP2 May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. Belongs to the SKAP family. Ubiquitously expressed. Present in platelets (at protein level). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 7p15.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; plasma membrane
Molecular Function:  protein binding
Biological Process:  B cell activation; negative regulation of cell population proliferation; signal transduction
Reference #:  O75563 (UniProtKB)
Alt. Names/Synonyms: Fyn-associated phosphoprotein SKAP55 homologue; MGC10411; MGC33304; PRAP; Pyk2/RAFTK-associated protein; RA70; Retinoic acid-induced protein 70; SAPS; SCAP2; SKAP-55HOM; SKAP-HOM; SKAP2; SKAP55 homolog; SKAP55R; Src family associated phosphoprotein 2; Src family-associated phosphoprotein 2; src kinase associated phosphoprotein 2; Src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; Src-associated adapter protein with PH and SH3 domains; src-associated adaptor protein
Gene Symbols: SKAP2
Molecular weight: 41,217 Da
Basal Isoelectric point: 4.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein